{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Barele M"],"funding":["NIHR"],"pagination":["1318-1328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10637040"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(11)"],"pubmed_abstract":["Background
Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA-associated BC who already have high contralateral BC (CBC) risk and potentially increased genetic susceptibility to radiation. We sought to investigate whether adjuvant RT for PBC increases the risk of CBC in patients with gBRCA1/2-associated BC.Methods
The gBRCA1/2 pathogenic variant carriers diagnosed with PBC were selected from the prospective International BRCA1/2 Carrier Cohort Study. We used multivariable Cox proportional hazards models to investigate the association between RT (yes vs no) and CBC risk. We further stratified for BRCA status and age at PBC diagnosis (<40 and >40 years"],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation."],"pmcid":["PMC10637040"],"funding_grant_id":["IS-BRC-1215-20007"],"pubmed_authors":["Genepso","Frost D","Tischkowitz M","Rhiem K","Antoniou AC","Kast K","Thomassen M","Foretova L","EMBRACE","Jager A","HEBON","de Bock GH","Dommering CJ","Engel C","Easton DF","Evans DG","Singer CF","Simard J","Brewer C","Andrieu N","Akdeniz D","van Leeuwen FE","van Asperen CJ","Gomez-Garcia EB","Olah E","Sattler MGA","Heemskerk-Gerritsen BAM","van Barele M","Hooning MJ","Schmidt MK","Nogues C","Ausems MGEM","Wevers M","Jakubowska A","Mooij TM","Izatt L","de la Hoya M"],"additional_accession":[]},"is_claimable":false,"name":"Contralateral breast cancer risk in patients with breast cancer and a germline-BRCA1/2 pathogenic variant undergoing radiation.","description":"Background
Radiation-induced secondary breast cancer (BC) may be a concern after radiation therapy (RT) for primary breast cancer (PBC), especially in young patients with germline (g)BRCA-associated BC who already have high contralateral BC (CBC) risk and potentially increased genetic susceptibility to radiation. We sought to investigate whether adjuvant RT for PBC increases the risk of CBC in patients with gBRCA1/2-associated BC.Methods
The gBRCA1/2 pathogenic variant carriers diagnosed with PBC were selected from the prospective International BRCA1/2 Carrier Cohort Study. We used multivariable Cox proportional hazards models to investigate the association between RT (yes vs no) and CBC risk. We further stratified for BRCA status and age at PBC diagnosis (<40 and >40 years","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T19:15:59.756Z","creation":"2025-04-04T19:15:59.756Z"},"accession":"S-EPMC10637040","cross_references":{"pubmed":["37369040"],"doi":["10.1093/jnci/djad116"]}}