{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Paiva Narciso N"],"funding":["NIBIB NIH HHS","NHLBI NIH HHS","National Institutes of Health","NIH HHS","National Science Foundation"],"pagination":["e2301265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10638947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(27)"],"pubmed_abstract":["Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical properties permissive to injectability and self-healing. However, not all hydrogels with transient crosslinks are easily extrudable. For this reason, two additional design parameters must be considered when formulating DCC-crosslinked hydrogels: 1) degree of functionalization (DoF) and 2) polymer molecular weight (MW). To investigate these parameters, hydrogels comprised of two recombinant biopolymers: 1) a hyaluronic acid (HA) modified with benzaldehyde and 2) an elastin-like protein (ELP) modified with hydrazine (ELP-HYD), are formulated. Several hydrogel families are synthesized with distinct HA MW and DoF while keeping the ELP-HYD component constant. The resulting hydrogels have a range of stiffnesse"],"journal":["Advanced healthcare materials"],"pubmed_title":["Design Parameters for Injectable Biopolymeric Hydrogels with Dynamic Covalent Chemistry Crosslinks."],"pmcid":["PMC10638947"],"funding_grant_id":["R01 EB027171","R01 HL142718","R25 HL147666","R01 HL151997","CBET2033302","R01HL151997","R01 EB027666"],"pubmed_authors":["Gilchrist AE","Trigo MLM","Navarro RS","Aviles Rodriguez G","Heilshorn SC","de Paiva Narciso N"],"additional_accession":[]},"is_claimable":false,"name":"Design Parameters for Injectable Biopolymeric Hydrogels with Dynamic Covalent Chemistry Crosslinks.","description":"Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical properties permissive to injectability and self-healing. However, not all hydrogels with transient crosslinks are easily extrudable. For this reason, two additional design parameters must be considered when formulating DCC-crosslinked hydrogels: 1) degree of functionalization (DoF) and 2) polymer molecular weight (MW). To investigate these parameters, hydrogels comprised of two recombinant biopolymers: 1) a hyaluronic acid (HA) modified with benzaldehyde and 2) an elastin-like protein (ELP) modified with hydrazine (ELP-HYD), are formulated. Several hydrogel families are synthesized with distinct HA MW and DoF while keeping the ELP-HYD component constant. The resulting hydrogels have a range of stiffnesse","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2025-04-04T01:59:32.413Z","creation":"2025-04-04T01:59:32.413Z"},"accession":"S-EPMC10638947","cross_references":{"pubmed":["37389811"],"doi":["10.1002/adhm.202301265"]}}