{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Llorente-Folch I"],"funding":["Science Foundation Ireland"],"pagination":["19664"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10640643"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The ketogenic diet is an emerging therapeutic approach for refractory epilepsy, as well as certain rare and neurodegenerative disorders. The main ketone body, β-hydroxybutyrate (BHB), is the primary energy substrate endogenously produced in a ketogenic diet, however, mechanisms of its therapeutic actions remain unknown. Here, we studied the effects of BHB on mitochondrial energetics, both in non-stimulated conditions and during glutamate-mediated hyperexcitation. We found that glutamate-induced hyperexcitation stimulated mitochondrial respiration in cultured cortical neurons, and that this response was greater in cultures supplemented with BHB than with glucose. BHB enabled a stronger and more sustained maximal uncoupled respiration, indicating that BHB enables neurons to respond more effi"],"journal":["Scientific reports"],"pubmed_title":["Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics."],"pmcid":["PMC10640643"],"funding_grant_id":["08/IN.1/B1949","14/JPND/B3077"],"pubmed_authors":["Llorente-Folch I","Watters O","Dussmann H","Prehn JHM","Connolly NMC"],"additional_accession":[]},"is_claimable":false,"name":"Ketone body β-hydroxybutyrate (BHB) preserves mitochondrial bioenergetics.","description":"The ketogenic diet is an emerging therapeutic approach for refractory epilepsy, as well as certain rare and neurodegenerative disorders. The main ketone body, β-hydroxybutyrate (BHB), is the primary energy substrate endogenously produced in a ketogenic diet, however, mechanisms of its therapeutic actions remain unknown. Here, we studied the effects of BHB on mitochondrial energetics, both in non-stimulated conditions and during glutamate-mediated hyperexcitation. We found that glutamate-induced hyperexcitation stimulated mitochondrial respiration in cultured cortical neurons, and that this response was greater in cultures supplemented with BHB than with glucose. BHB enabled a stronger and more sustained maximal uncoupled respiration, indicating that BHB enables neurons to respond more effi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-21T15:57:27.814Z","creation":"2025-04-21T15:57:27.814Z"},"accession":"S-EPMC10640643","cross_references":{"pubmed":["37952048"],"doi":["10.1038/s41598-023-46776-8"]}}