{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(21)"],"submitter":["Lu Z"],"pubmed_abstract":["<i>Mycoplasma gallisepticum</i> (MG) is recognized as a principal causative agent of avian chronic respiratory disease, inflicting substantial economic losses upon the poultry industry. However, the extensive use of conventional antibiotics has resulted in the emergence of drug resistance and various challenges in their clinical application. Consequently, there is an urgent need to identify effective therapeutic agents for the prevention and treatment of mycoplasma-induced respiratory disease in avian species. AMP-activated protein kinase (AMPK) holds significant importance as a regulator of cellular energy metabolism and possesses the capacity to exert an anti-inflammatory effect by virtue of its downstream protein, SIRT1. This pathway has shown promise in counteracting the inflammatory r"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["7388"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10650132"],"repository":["biostudies-literature"],"pubmed_title":["Quercetin and AMPK: A Dynamic Duo in Alleviating MG-Induced Inflammation via the AMPK/SIRT1/NF-κB Pathway."],"pmcid":["PMC10650132"],"pubmed_authors":["Ishfaq M","Li X","Gao B","Wang B","Lu X","Lu Z","Zhang X","Han Y","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"Quercetin and AMPK: A Dynamic Duo in Alleviating MG-Induced Inflammation via the AMPK/SIRT1/NF-κB Pathway.","description":"<i>Mycoplasma gallisepticum</i> (MG) is recognized as a principal causative agent of avian chronic respiratory disease, inflicting substantial economic losses upon the poultry industry. However, the extensive use of conventional antibiotics has resulted in the emergence of drug resistance and various challenges in their clinical application. Consequently, there is an urgent need to identify effective therapeutic agents for the prevention and treatment of mycoplasma-induced respiratory disease in avian species. AMP-activated protein kinase (AMPK) holds significant importance as a regulator of cellular energy metabolism and possesses the capacity to exert an anti-inflammatory effect by virtue of its downstream protein, SIRT1. This pathway has shown promise in counteracting the inflammatory r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T11:00:36.442Z","creation":"2025-04-04T11:00:36.442Z"},"accession":"S-EPMC10650132","cross_references":{"pubmed":["37959807"],"doi":["10.3390/molecules28217388"]}}