biostudies-literatureMarcozzi SMinistero della SaluteFondazione Cariplo2195-2211https://www.ebi.ac.uk/biostudies/studies/S-EPMC10651584biostudies-literatureUnknown45(4)Frailty is an age-related condition characterized by a multisystem functional decline, increased vulnerability to stressors, and adverse health outcomes. Quantifying the degree of frailty in humans and animals is a health measure useful for translational geroscience research. Two frailty measurements, namely the frailty phenotype (FP) and the clinical frailty index (CFI), have been validated in mice and are frequently applied in preclinical research. However, these two tools are based on different concepts and do not necessarily identify the same mice as frail. In particular, the FP is based on a dichotomous classification that suffers from high sample size requirements and misclassification problems. Based on the monthly longitudinal non-invasive assessment of frailty in a large cohort ofGeroScienceComprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.PMC106515842016-1006Ricerca CorrenteRCR-2019-23669121Brunetti DSegala AGaetano CMongelli APuca ABoschi FGiuliani MEOrlando FNisoli EPiacenza FValerio AProvinciali MBigossi GGiacconi RCardelli MLattanzio FMalavolta MMarcozzi SfalseComprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.Frailty is an age-related condition characterized by a multisystem functional decline, increased vulnerability to stressors, and adverse health outcomes. Quantifying the degree of frailty in humans and animals is a health measure useful for translational geroscience research. Two frailty measurements, namely the frailty phenotype (FP) and the clinical frailty index (CFI), have been validated in mice and are frequently applied in preclinical research. However, these two tools are based on different concepts and do not necessarily identify the same mice as frail. In particular, the FP is based on a dichotomous classification that suffers from high sample size requirements and misclassification problems. Based on the monthly longitudinal non-invasive assessment of frailty in a large cohort of2023-01-01T00:00:00Z2023 Aug2025-04-19T16:15:22.396Z2025-04-19T16:15:22.396ZS-EPMC106515843670299010.1007/s11357-023-00737-1