{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Swets MC"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["7374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10651917"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and"],"journal":["Nature communications"],"pubmed_title":["Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity."],"pmcid":["PMC10651917"],"funding_grant_id":["NIHR201395","NIHR302829","215091/Z/18/Z","MC_PC_19025","DRF-2018-11-ST2-004","223164/Z/21/Z","MC_PC_20004","HDRUK2021.0125","216606/Z/19/Z","CO-CIN-01"],"pubmed_authors":["Gupta R","Baillie JK","Swets MC","Nguyen-Van-Tam JS","Semple MG","Docherty A","Millar JE","Openshaw P","Spata E","Bretherick AD","Horby PW","Lone N","Kerr S","Groeneveld GH","Dunning J","Harrison E","Harrison D","Rowan K","McCurrach F","Brown AB","Staplin N","ISARIC4C Investigators","Young N","Scott-Brown J"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.","description":"Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula: see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula: see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula: see text] values. We found that the correlation of [Formula: see text] with the reference standard ([Formula: see text]/[Formula: see text] ratio) improves substantially when excluding [Formula: see text] and refer to this measure as [Formula: see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula: see text] is predictive of mortality, and","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-01T08:13:59.858Z","creation":"2024-11-14T13:11:18.047Z"},"accession":"S-EPMC10651917","cross_references":{"pubmed":["37968269"],"doi":["10.1038/s41467-023-42205-6"]}}