{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoek KL"],"funding":["HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","NIAID NIH HHS","CSRD VA","National Science Foundation"],"pagination":["e0032223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10652940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(11)"],"pubmed_abstract":["One of the major contributors to child mortality in the world is diarrheal diseases, with an estimated 800,000 deaths per year. Many pathogens are causative agents of these illnesses, including the enteropathogenic or enterohemorrhagic forms of <i>Escherichia coli</i>. These bacteria are characterized by their ability to cause attaching and effacing lesions in the gut mucosa. Although much has been learned about the pathogenicity of these organisms and the immune response against them, the role of the intestinal microbiota during these infections is not well characterized. Infection of mice with <i>E. coli</i> requires pre-treatment with antibiotics in most mouse models, which hinders the study of the microbiota in an undisturbed environment. Using <i>Citrobacter rodentium</i> as a murine "],"journal":["Infection and immunity"],"pubmed_title":["Turicibacterales protect mice from severe <i>Citrobacter rodentium</i> infection."],"pmcid":["PMC10652940"],"funding_grant_id":["R01 DK131104","R01DK111671","I01 CX002473","1937963","P30DK058404","P30 DK058404","I01 CX002171","R01DK128200","R01 DK128200","R01 AI168302"],"pubmed_authors":["Shealy N","Latour YL","McClanahan KG","Byndloss MX","Wilson KT","Piazuelo MB","Vallance BA","Olivares-Villagomez D","Hoek KL"],"additional_accession":[]},"is_claimable":false,"name":"Turicibacterales protect mice from severe <i>Citrobacter rodentium</i> infection.","description":"One of the major contributors to child mortality in the world is diarrheal diseases, with an estimated 800,000 deaths per year. Many pathogens are causative agents of these illnesses, including the enteropathogenic or enterohemorrhagic forms of <i>Escherichia coli</i>. These bacteria are characterized by their ability to cause attaching and effacing lesions in the gut mucosa. Although much has been learned about the pathogenicity of these organisms and the immune response against them, the role of the intestinal microbiota during these infections is not well characterized. Infection of mice with <i>E. coli</i> requires pre-treatment with antibiotics in most mouse models, which hinders the study of the microbiota in an undisturbed environment. Using <i>Citrobacter rodentium</i> as a murine ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-22T15:37:17.921Z","creation":"2025-04-06T01:24:07.62Z"},"accession":"S-EPMC10652940","cross_references":{"pubmed":["37800916"],"doi":["10.1128/iai.00322-23"]}}