{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Philip AA"],"funding":["HHS | National Institutes of Health","Lawrence M. Blatt Endowment","GIVAX, INC"],"pagination":["e0060323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10652971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy."],"journal":["Microbiology resource announcements"],"pubmed_title":["T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain."],"pmcid":["PMC10652971"],"funding_grant_id":["R21AI44881"],"pubmed_authors":["Patton JT","Yi G","Philip AA","Agbemabiese CA"],"additional_accession":[]},"is_claimable":false,"name":"T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain.","description":"The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-22T15:32:21.986Z","creation":"2025-04-06T01:25:03.204Z"},"accession":"S-EPMC10652971","cross_references":{"pubmed":["37819123"],"doi":["10.1128/MRA.00603-23"]}}