{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(45)"],"submitter":["Kazakova E"],"pubmed_abstract":["Yellow fever virus (YFV) transmitted by infected mosquitoes causes an acute viral disease for which there are no approved small-molecule therapeutics. Our recently developed machine learning models for YFV inhibitors led to the selection of a new pyrazolesulfonamide derivative <b>RCB16003</b> with acceptable <i>in vitro</i> activity. We report that the <i>N</i>-phenyl-1-(phenylsulfonyl)-1<i>H</i>-1,2,4-triazol-3-amine class, which was recently identified as active non-nucleoside reverse transcriptase inhibitors against HIV-1, can also be repositioned as inhibitors of yellow fever virus replication. As compared to other <i>Flaviviridae</i> or <i>Togaviridae</i> family viruses tested, both compounds <b>RCB16003</b> and <b>RCB16007</b> demonstrate selectivity for YFV over related viruses, wit"],"journal":["ACS omega"],"pagination":["42951-42965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10653066"],"repository":["biostudies-literature"],"pubmed_title":["1-Sulfonyl-3-amino-1<i>H</i>-1,2,4-triazoles as Yellow Fever Virus Inhibitors: Synthesis and Structure-Activity Relationship."],"pmcid":["PMC10653066"],"pubmed_authors":["Riabova O","Ekins S","Kazakova E","Makarov V","Puhl AC","Lane TR","Jones T"],"additional_accession":[]},"is_claimable":false,"name":"1-Sulfonyl-3-amino-1<i>H</i>-1,2,4-triazoles as Yellow Fever Virus Inhibitors: Synthesis and Structure-Activity Relationship.","description":"Yellow fever virus (YFV) transmitted by infected mosquitoes causes an acute viral disease for which there are no approved small-molecule therapeutics. Our recently developed machine learning models for YFV inhibitors led to the selection of a new pyrazolesulfonamide derivative <b>RCB16003</b> with acceptable <i>in vitro</i> activity. We report that the <i>N</i>-phenyl-1-(phenylsulfonyl)-1<i>H</i>-1,2,4-triazol-3-amine class, which was recently identified as active non-nucleoside reverse transcriptase inhibitors against HIV-1, can also be repositioned as inhibitors of yellow fever virus replication. As compared to other <i>Flaviviridae</i> or <i>Togaviridae</i> family viruses tested, both compounds <b>RCB16003</b> and <b>RCB16007</b> demonstrate selectivity for YFV over related viruses, wit","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T09:30:22.778Z","creation":"2025-04-04T09:30:22.778Z"},"accession":"S-EPMC10653066","cross_references":{"pubmed":["38024733"],"doi":["10.1021/acsomega.3c06106"]}}