biostudies-literatureGarg PMNHLBI NIH HHS191-197https://www.ebi.ac.uk/biostudies/studies/S-EPMC10653206biostudies-literatureUnknown2(3)<h4>Background</h4>We sought to investigate the clinical determinants and outcomes of cholestasis in preterm infants with surgical necrotizing enterocolitis (sNEC).<h4>Methods</h4>Retrospective comparison of clinical information in preterm infants who developed cholestasis vs those who did not.<h4>Results</h4>Sixty-two (62/91, 68.1%) infants with NEC developed cholestasis at any time following the onset of illness. Cholestasis was seen more frequently in those who had received ionotropic support at 24 hours following sNEC diagnosis (87.1% vs 58.6%; <i>p</i> = 0.002), had higher mean C-reactive protein levels 2 weeks after NEC diagnosis (<i>p</i> = 0.009), had blood culture-positive sepsis [25 (40.3%) vs 4 (13.8%); <i>p</i> = 0.011], received parenteral nutrition (PN) for longer durations (Newborn (Clarksville, Md.)Clinical Correlates of Cholestasis in Preterm Infants with Surgical Necrotizing Enterocolitis.PMC10653206R01 HL133022Yi JMaheshwari ARodriguez RJRauh JLGarg PPGarg PMMcDonald AGPittman IPremkumar MHWeis VGLadd MRWelch CfalseClinical Correlates of Cholestasis in Preterm Infants with Surgical Necrotizing Enterocolitis.<h4>Background</h4>We sought to investigate the clinical determinants and outcomes of cholestasis in preterm infants with surgical necrotizing enterocolitis (sNEC).<h4>Methods</h4>Retrospective comparison of clinical information in preterm infants who developed cholestasis vs those who did not.<h4>Results</h4>Sixty-two (62/91, 68.1%) infants with NEC developed cholestasis at any time following the onset of illness. Cholestasis was seen more frequently in those who had received ionotropic support at 24 hours following sNEC diagnosis (87.1% vs 58.6%; <i>p</i> = 0.002), had higher mean C-reactive protein levels 2 weeks after NEC diagnosis (<i>p</i> = 0.009), had blood culture-positive sepsis [25 (40.3%) vs 4 (13.8%); <i>p</i> = 0.011], received parenteral nutrition (PN) for longer durations (2023-01-01T00:00:00Z2023 Jul-Sep2025-04-04T13:16:09.771Z2025-04-04T13:16:09.771ZS-EPMC106532063797492910.5005/jp-journals-11002-0069