{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ciganda M"],"funding":["NIAID NIH HHS","PEDECIBA and are members of ANII research career","NIH"],"pagination":["1881-1895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10653379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(12)"],"pubmed_abstract":["<i>Trypanosoma brucei</i> occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping of the protein landscape of the parasite both to evade surveillance and face changing metabolic demands. In kinetoplastid protozoa, including <i>T. brucei</i>, posttranscriptional control mechanisms are the primary means of gene regulation, and these are often mediated by RNA-binding proteins. DRBD18 is a <i>T. brucei</i> RNA-binding protein that reportedly interacts with ribosomal proteins and translation factors. Here, we tested a role for DRBD18 in translational control. We validate the DRBD18 interaction with translating ribosomes and the translation in"],"journal":["RNA (New York, N.Y.)"],"pubmed_title":["Translational control by <i>Trypanosoma brucei</i> DRBD18 contributes to the maintenance of the procyclic state."],"pmcid":["PMC10653379"],"funding_grant_id":["R01AI141557","R01 AI141557"],"pubmed_authors":["Dubey AP","Ciganda M","Smircich P","Read LK","Qu J","Shen S","Pandey P","Sotelo-Silveira J","Smith JT"],"additional_accession":[]},"is_claimable":false,"name":"Translational control by <i>Trypanosoma brucei</i> DRBD18 contributes to the maintenance of the procyclic state.","description":"<i>Trypanosoma brucei</i> occupies distinct niches throughout its life cycle, within both the mammalian and tsetse fly hosts. The immunological and biochemical complexity and variability of each of these environments require a reshaping of the protein landscape of the parasite both to evade surveillance and face changing metabolic demands. In kinetoplastid protozoa, including <i>T. brucei</i>, posttranscriptional control mechanisms are the primary means of gene regulation, and these are often mediated by RNA-binding proteins. DRBD18 is a <i>T. brucei</i> RNA-binding protein that reportedly interacts with ribosomal proteins and translation factors. Here, we tested a role for DRBD18 in translational control. We validate the DRBD18 interaction with translating ribosomes and the translation in","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-04T09:50:05.155Z","creation":"2025-02-19T01:17:08.382Z"},"accession":"S-EPMC10653379","cross_references":{"pubmed":["37730435"],"doi":["10.1261/rna.079625.123"]}}