biostudies-literatureUnknown18(11)Gomes DF<h4>Introduction</h4>Age-related macular degeneration (AMD) is an eye disease that occurs in patients over 50 years old. Early diagnosis enables timely treatment to stabilize disease progression. However, the fact that the disease is asymptomatic in its early stages can delay treatment until it progresses. As such, screening in specific contexts can be an early detection tool to reduce the clinical and social impact of the disease.<h4>Objective</h4>Assess the effectiveness of screening methods for early detection of AMD in adults aged 50 years or older.<h4>Methods</h4>A systematic review of comparative observational studies on AMD screening methods in those aged 50 years or older, compared with no screening or any other strategy. A literature search was conducted in the MEDLINE (via PubMedPloS onee0294398https://www.ebi.ac.uk/biostudies/studies/S-EPMC10653496biostudies-literatureClinical effectiveness of screening for age-related macular degeneration: A systematic review.PMC10653496Silva ENDCurado DDSPGomes RMGomes DFRamos MCLeite BFfalseClinical effectiveness of screening for age-related macular degeneration: A systematic review.<h4>Introduction</h4>Age-related macular degeneration (AMD) is an eye disease that occurs in patients over 50 years old. Early diagnosis enables timely treatment to stabilize disease progression. However, the fact that the disease is asymptomatic in its early stages can delay treatment until it progresses. As such, screening in specific contexts can be an early detection tool to reduce the clinical and social impact of the disease.<h4>Objective</h4>Assess the effectiveness of screening methods for early detection of AMD in adults aged 50 years or older.<h4>Methods</h4>A systematic review of comparative observational studies on AMD screening methods in those aged 50 years or older, compared with no screening or any other strategy. A literature search was conducted in the MEDLINE (via PubMed2023-01-01T00:00:00Z20232026-06-01T21:43:28.431Z2025-04-19T16:13:28.163ZS-EPMC106534963797199210.1371/journal.pone.0294398