biostudies-literatureUnknown19(3)Sanchez-Garcia Ano funding associated with the workThe bacille Calmette-Guérin (BCG) vaccine is administered in many countries as part of their vaccination schedules. Epidemiologic studies have suggested a possible benefit of this vaccine in the context of the COVID-19 pandemic and other respiratory infections. We aimed to assess the safety of this intervention in BCG-primed adults. Adult health care workers (<i>n</i> = 451) received a single intradermal application of the BCG vaccine (Tokyo 172 strain) in the deltoid region of the right arm. Follow-up (30 days) calls and clinical inspections were guided using a standardized data sheet to assess local and systemic reactions. Early local reactions were common at 24 h and 7 days, such as erythema (74.9%, 69.2%), induration (55.7%, 59%), a papule (53.4%, 47.7%), and edema (48.3%, 38.1). LocalHuman vaccines & immunotherapeutics2271760https://www.ebi.ac.uk/biostudies/studies/S-EPMC10653682biostudies-literatureThe safety of BCG revaccination in the context of COVID-19.PMC10653682Rodriguez-Gutierrez RGonzalez-Gonzalez JGTamez-Guerra RSanchez-Garcia ABarrera FJGonzalez-Saldivar GRamirez-Garcia LAfalseThe safety of BCG revaccination in the context of COVID-19.The bacille Calmette-Guérin (BCG) vaccine is administered in many countries as part of their vaccination schedules. Epidemiologic studies have suggested a possible benefit of this vaccine in the context of the COVID-19 pandemic and other respiratory infections. We aimed to assess the safety of this intervention in BCG-primed adults. Adult health care workers (<i>n</i> = 451) received a single intradermal application of the BCG vaccine (Tokyo 172 strain) in the deltoid region of the right arm. Follow-up (30 days) calls and clinical inspections were guided using a standardized data sheet to assess local and systemic reactions. Early local reactions were common at 24 h and 7 days, such as erythema (74.9%, 69.2%), induration (55.7%, 59%), a papule (53.4%, 47.7%), and edema (48.3%, 38.1). Local2023-01-01T00:00:00Z2023 Dec2025-04-04T03:20:29.73Z2025-04-04T03:20:29.73ZS-EPMC106536823793643410.1080/21645515.2023.2271760