biostudies-literatureUnknown4(6)Zhang QObstructive sleep apnea (OSA) can lead to sleep deprivation, accidents, and cardiovascular diseases. However, research on the short-term effects of air pollutants on OSA severity is limited and inconsistent. We conducted a novel case time series analysis using a nationwide dataset among Huawei smart device users to assess the association between air pollution and OSA severity in a population at moderate-to-severe risk of OSA. Fixed-effects regression models were used to assess the associations between air pollution and the risk of OSA exacerbation, apnea-hypopnea index (AHI), and oxygen saturation. A total of 51,842 participants who were at moderate-to-severe risk of OSA (mean age [SD]: 45.4 [11.0], 95.5% male) were included, with 6,232,056 person-days of monitoring. The associations of fiInnovation (Cambridge (Mass.))100528https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654035biostudies-literatureAir pollution may increase the sleep apnea severity: A nationwide analysis of smart device-based monitoring.PMC10654035Guo YZhu XLi AWang HLiu CChen RZhang QKan HfalseAir pollution may increase the sleep apnea severity: A nationwide analysis of smart device-based monitoring.Obstructive sleep apnea (OSA) can lead to sleep deprivation, accidents, and cardiovascular diseases. However, research on the short-term effects of air pollutants on OSA severity is limited and inconsistent. We conducted a novel case time series analysis using a nationwide dataset among Huawei smart device users to assess the association between air pollution and OSA severity in a population at moderate-to-severe risk of OSA. Fixed-effects regression models were used to assess the associations between air pollution and the risk of OSA exacerbation, apnea-hypopnea index (AHI), and oxygen saturation. A total of 51,842 participants who were at moderate-to-severe risk of OSA (mean age [SD]: 45.4 [11.0], 95.5% male) were included, with 6,232,056 person-days of monitoring. The associations of fi2023-01-01T00:00:00Z2023 Nov2025-04-21T18:24:46.444Z2025-04-05T17:12:31.635ZS-EPMC106540353802813610.1016/j.xinn.2023.100528