biostudies-literatureUnknown11Sun D<h4>Background</h4>Wound management of diabetic foot ulcers (DFUs) is a complex and challenging task, and existing strategies fail to meet clinical needs. Therefore, it is important to develop novel drug candidates and discover new therapeutic targets. However, reports on peptides as molecular probes for resolving issues related to DFUs remain rare. This study utilized peptide RL-QN15 as an exogenous molecular probe to investigate the underlying mechanism of endogenous non-coding RNA in DFU wound healing. The aim was to generate novel insights for the clinical management of DFUs and identify potential drug targets.<h4>Methods</h4>We investigated the wound-healing efficiency of peptide RL-QN15 under diabetic conditions using <i>in vitro</i> and <i>in vivo</i> experimental models. RNA sequenBurns & traumatkad035https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654477biostudies-literaturePeptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis.PMC10654477Li JHu YLi CLiu NFu ZKang ZYang XLi YGuo KLi SZhang YSun DWang YWang ZWu YSun JfalsePeptide RL-QN15 promotes wound healing of diabetic foot ulcers through p38 mitogen-activated protein kinase and smad3/miR-4482-3p/vascular endothelial growth factor B axis.<h4>Background</h4>Wound management of diabetic foot ulcers (DFUs) is a complex and challenging task, and existing strategies fail to meet clinical needs. Therefore, it is important to develop novel drug candidates and discover new therapeutic targets. However, reports on peptides as molecular probes for resolving issues related to DFUs remain rare. This study utilized peptide RL-QN15 as an exogenous molecular probe to investigate the underlying mechanism of endogenous non-coding RNA in DFU wound healing. The aim was to generate novel insights for the clinical management of DFUs and identify potential drug targets.<h4>Methods</h4>We investigated the wound-healing efficiency of peptide RL-QN15 under diabetic conditions using <i>in vitro</i> and <i>in vivo</i> experimental models. RNA sequen2023-01-01T00:00:00Z20232025-04-21T18:24:35.275Z2025-04-05T17:12:29.26ZS-EPMC106544773802644310.1093/burnst/tkad035