biostudies-literatureUnknown35Kwon S<h4>Background</h4>Shift work has been reported to have several harmful effects on the human body. However, a small number of studies have evaluated the association between shift work and adverse effects on the thyroid. In our longitudinal study, we examined the causal association between shift work and the risk of hypothyroidism.<h4>Methods</h4>A Kangbuk Samsung Cohort Study was conducted on 112,648 men without thyroid disease at baseline who were followed up at least once between 2012 and 2019. Shift work status and shift schedule types were categorized using standardized questionnaires. Hypothyroidism was defined using the reference ranges of serum thyroid-stimulating hormones and free thyroxine levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident hypothyroidism wAnnals of occupational and environmental medicinee41https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654535biostudies-literatureAssociation between shift work and the risk of hypothyroidism in adult male workers in Korea: a cohort study.PMC10654535Jeong YKim DJeong JKwon SSeo ELee JLee YKim JLee WfalseAssociation between shift work and the risk of hypothyroidism in adult male workers in Korea: a cohort study.<h4>Background</h4>Shift work has been reported to have several harmful effects on the human body. However, a small number of studies have evaluated the association between shift work and adverse effects on the thyroid. In our longitudinal study, we examined the causal association between shift work and the risk of hypothyroidism.<h4>Methods</h4>A Kangbuk Samsung Cohort Study was conducted on 112,648 men without thyroid disease at baseline who were followed up at least once between 2012 and 2019. Shift work status and shift schedule types were categorized using standardized questionnaires. Hypothyroidism was defined using the reference ranges of serum thyroid-stimulating hormones and free thyroxine levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident hypothyroidism w2023-01-01T00:00:00Z20232025-04-21T18:25:05.462Z2025-04-05T17:12:34.867ZS-EPMC106545353802927510.35371/aoem.2023.35.e41