{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Langenecker SA"],"funding":["NIMH NIH HHS"],"pagination":["1-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(1)"],"pubmed_abstract":["<h4>Background</h4>Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri.<h4>Methods</h4>Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (<i>"],"journal":["Biological psychiatry global open science"],"pubmed_title":["Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial."],"pmcid":["PMC10654545"],"funding_grant_id":["R33 MH116080","R61 MH116080","T32 MH073517"],"pubmed_authors":["Westlund Schreiner M","Jacobs RH","Dillahunt A","Kerig PK","Kaufman E","Galloway JA","Jago D","Pazdera M","Thomas L","Bessette KL","Crowell SE","Welsh RC","Pocius SL","Feldman DA","Farstead B","Watkins ER","Langenecker SA","Roberts H","Bakian A"],"additional_accession":[]},"is_claimable":false,"name":"Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.","description":"<h4>Background</h4>Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri.<h4>Methods</h4>Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (<i>","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-05-28T15:42:27.262Z","creation":"2024-11-13T09:07:48.59Z"},"accession":"S-EPMC10654545","cross_references":{"pubmed":["38021251"],"doi":["10.1016/j.bpsgos.2023.08.012"]}}