biostudies-literatureLangenecker SANIMH NIH HHS1-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654545biostudies-literatureUnknown4(1)<h4>Background</h4>Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri.<h4>Methods</h4>Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (<i>Biological psychiatry global open scienceRumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.PMC10654545R33 MH116080R61 MH116080T32 MH073517Westlund Schreiner MJacobs RHDillahunt AKerig PKKaufman EGalloway JAJago DPazdera MThomas LBessette KLCrowell SEWelsh RCPocius SLFeldman DAFarstead BWatkins ERLangenecker SARoberts HBakian AfalseRumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial.<h4>Background</h4>Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri.<h4>Methods</h4>Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (<i>2024-01-01T00:00:00Z2024 Jan2026-05-28T15:42:27.262Z2024-11-13T09:07:48.59ZS-EPMC106545453802125110.1016/j.bpsgos.2023.08.012