{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zeng L"],"funding":["National Natural Science Foundation of China"],"pagination":["100737"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654591"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31"],"pubmed_abstract":["Tumor-specific antigens (TSAs) are crucial for tumor-specific immune response that reduces tumor burden and thus serve as important targets for immunotherapy. Identification of novel TSAs can provide new strategies for immunotherapies. In this study, we demonstrated that the upstream open reading frame (uORF) of <i>RNF10</i> encodes an antigenic peptide (RNF10 uPeptide), capable of eliciting a T cell-mediated anti-tumor immune response. We initially demonstrated the immunogenicity of the RNF10 uPeptide in a CT26 tumor mouse model, by showing that its epitope was specifically recognized by CD8+ T cells. Vaccination of mice with the long form of the RNF10 uPeptide conferred strong anti-tumor activity. Next, we proved that the human <i>RNF10</i> uORF could be translated. In addition, we predi"],"journal":["Molecular therapy oncolytics"],"pubmed_title":["An epitope encoded by uORF of <i>RNF10</i> elicits a therapeutic anti-tumor immune response."],"pmcid":["PMC10654591"],"funding_grant_id":["32000430"],"pubmed_authors":["Ji Q","Zhang J","Zeng L","Zhu X","Zheng W","Wang J","Meng Y","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"An epitope encoded by uORF of <i>RNF10</i> elicits a therapeutic anti-tumor immune response.","description":"Tumor-specific antigens (TSAs) are crucial for tumor-specific immune response that reduces tumor burden and thus serve as important targets for immunotherapy. Identification of novel TSAs can provide new strategies for immunotherapies. In this study, we demonstrated that the upstream open reading frame (uORF) of <i>RNF10</i> encodes an antigenic peptide (RNF10 uPeptide), capable of eliciting a T cell-mediated anti-tumor immune response. We initially demonstrated the immunogenicity of the RNF10 uPeptide in a CT26 tumor mouse model, by showing that its epitope was specifically recognized by CD8+ T cells. Vaccination of mice with the long form of the RNF10 uPeptide conferred strong anti-tumor activity. Next, we proved that the human <i>RNF10</i> uORF could be translated. In addition, we predi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-16T06:49:04.285Z","creation":"2025-02-19T00:38:45.782Z"},"accession":"S-EPMC10654591","cross_references":{"pubmed":["38020063"],"doi":["10.1016/j.omto.2023.100737"]}}