{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Villa-Consuegra S"],"funding":["Ministerio de Educación y Formación Profesional","Ministerio de Ciencia e Innovación","Gobierno de Espana Ministerio de Ciencia e Innovacion"],"pagination":["108339"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654595"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(11)"],"pubmed_abstract":["During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metaphase I and in the mid-spindle during anaphase I, as in mitosis; but in the absence of an intervening S phase, the importin α Imp1 propitiates its release from the spindle midzone to re-localize at kinetochores during meiotic interkinesis. We show that \"error-correction\" activity of kinetochore re-localized Aurora B becomes essential to erase monopolar arrangements from anaphase I, a prerequisite to satisfy the spindle assembly checkpoint (SAC) and to generate proper bipolar arrays at the onset o"],"journal":["iScience"],"pubmed_title":["Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition."],"pmcid":["PMC10654595"],"funding_grant_id":["PID2019-111124GB-I00","FPU18/04507"],"pubmed_authors":["Tallada VA","Villa-Consuegra S","Jimenez J"],"additional_accession":[]},"is_claimable":false,"name":"Aurora B kinase erases monopolar microtubule-kinetochore arrays at the meiosis I-II transition.","description":"During meiosis, faithful chromosome segregation requires monopolar spindle microtubule-kinetochore arrays in MI to segregate homologous chromosomes, but bipolar in MII to segregate sister chromatids. Using fission yeasts, we found that the universal Aurora B kinase localizes to kinetochores in metaphase I and in the mid-spindle during anaphase I, as in mitosis; but in the absence of an intervening S phase, the importin α Imp1 propitiates its release from the spindle midzone to re-localize at kinetochores during meiotic interkinesis. We show that \"error-correction\" activity of kinetochore re-localized Aurora B becomes essential to erase monopolar arrangements from anaphase I, a prerequisite to satisfy the spindle assembly checkpoint (SAC) and to generate proper bipolar arrays at the onset o","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-21T18:23:25.165Z","creation":"2025-04-05T17:12:19.633Z"},"accession":"S-EPMC10654595","cross_references":{"pubmed":["38026180"],"doi":["10.1016/j.isci.2023.108339"]}}