biostudies-literatureUnknown6(11)Kabirian R<h4>Importance</h4>Younger survivors of breast cancer frequently report more treatment-related symptoms, mostly related to the menopausal transition.<h4>Objective</h4>To assess factors associated with chemotherapy-related amenorrhea (CRA) and to evaluate its association with long-term quality of life (QOL).<h4>Design, setting, and participants</h4>The prospective, longitudinal Cancer Toxicities Study, a multicenter French cohort study, includes women with a diagnosis of stage I to III breast cancer and collects data approximately yearly after diagnosis. The current study reports outcomes up to 4 years after diagnosis for participants enrolled from 2012 to 2017. Participants included premenopausal women younger than 50 years treated with chemotherapy and not receiving adjuvant ovarian functJAMA network opene2343910https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654794biostudies-literatureChemotherapy-Related Amenorrhea and Quality of Life Among Premenopausal Women With Breast Cancer.PMC10654794Dhaini Merimeche AKabirian RTredan OLevy CHavas JMartin ALGiacchetti SDalenc FEverhard SPistilli BRouanet PVaz-Luis IFranzoi MAGuillermet SLambertini MFerrero JMDi Meglio ACottu PCoutant CPetit TfalseChemotherapy-Related Amenorrhea and Quality of Life Among Premenopausal Women With Breast Cancer.<h4>Importance</h4>Younger survivors of breast cancer frequently report more treatment-related symptoms, mostly related to the menopausal transition.<h4>Objective</h4>To assess factors associated with chemotherapy-related amenorrhea (CRA) and to evaluate its association with long-term quality of life (QOL).<h4>Design, setting, and participants</h4>The prospective, longitudinal Cancer Toxicities Study, a multicenter French cohort study, includes women with a diagnosis of stage I to III breast cancer and collects data approximately yearly after diagnosis. The current study reports outcomes up to 4 years after diagnosis for participants enrolled from 2012 to 2017. Participants included premenopausal women younger than 50 years treated with chemotherapy and not receiving adjuvant ovarian funct2023-01-01T00:00:00Z2023 Nov2026-06-02T01:17:24.314Z2025-04-06T02:39:43.158ZS-EPMC106547943797173910.1001/jamanetworkopen.2023.43910