biostudies-literatureUnknown10(11)Devigili G<h4>Background</h4>Patients with Parkinson's disease (PD) and <i>GBA</i> gene mutations (GBA-PD) develop nonmotor complications more frequently than noncarriers. However, an objective characterization of both cardiovascular and sudomotor autonomic dysfunction using extensive clinical and instrumental measures has never been provided so far. Survival is reduced in GBA-PD regardless of age and dementia, suggesting that other hitherto unrecognized factors are involved.<h4>Objectives</h4>To provide instrumental measures of pattern and severity of autonomic dysfunction in GBA-PD and explore their correlation with other non-motor symptoms and implications for clinical practice.<h4>Methods</h4>In this cross-sectional study, 21 GBA-PD and 24 matched PD noncarriers underwent extensive assessment ofMovement disorders clinical practice1620-1638https://www.ebi.ac.uk/biostudies/studies/S-EPMC10654845biostudies-literatureUnraveling Autonomic Dysfunction in GBA-Related Parkinson's Disease.PMC10654845Invernizzi FCilia RDevigili GStraccia GElia AEAndreasi NGGaravaglia BEleopra RFedeli APiacentini SHMJPrioni SRomito LMCereda EAmami PfalseUnraveling Autonomic Dysfunction in GBA-Related Parkinson's Disease.<h4>Background</h4>Patients with Parkinson's disease (PD) and <i>GBA</i> gene mutations (GBA-PD) develop nonmotor complications more frequently than noncarriers. However, an objective characterization of both cardiovascular and sudomotor autonomic dysfunction using extensive clinical and instrumental measures has never been provided so far. Survival is reduced in GBA-PD regardless of age and dementia, suggesting that other hitherto unrecognized factors are involved.<h4>Objectives</h4>To provide instrumental measures of pattern and severity of autonomic dysfunction in GBA-PD and explore their correlation with other non-motor symptoms and implications for clinical practice.<h4>Methods</h4>In this cross-sectional study, 21 GBA-PD and 24 matched PD noncarriers underwent extensive assessment of2023-01-01T00:00:00Z2023 Nov2025-04-21T18:20:34.802Z2025-04-05T17:12:03.117ZS-EPMC106548453802651410.1002/mdc3.13892