{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeng M"],"funding":["NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["e1008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10656098"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(11)"],"pubmed_abstract":["<h4>Objectives</h4>Diagnosis of pneumonia is challenging in critically ill, intubated patients due to limited diagnostic modalities. Endotracheal aspirate (EA) cultures are standard of care in many ICUs; however, frequent EA contamination leads to unnecessary antibiotic use. Nonbronchoscopic bronchoalveolar lavage (NBBL) obtains sterile, alveolar cultures, avoiding contamination. However, paired NBBL and EA sampling in the setting of a lack of gold standard for airway culture is a novel approach to improve culture accuracy and limit antibiotic use in the critically ill patients.<h4>Design</h4>We designed a pilot study to test respiratory culture accuracy between EA and NBBL. Adult, intubated patients with suspected pneumonia received concurrent EA and NBBL cultures by registered respirator"],"journal":["Critical care explorations"],"pubmed_title":["Nonbronchoscopic Bronchoalveolar Lavage Improves Respiratory Culture Accuracy in Critically Ill Patients."],"pmcid":["PMC10656098"],"funding_grant_id":["R01 HL155064","T32 HL155005","R35 GM149240"],"pubmed_authors":["Mehkri O","Mireles-Cabodevila E","Khouli H","Vachharajani V","Yerke J","Jeng M","Orsini EM","Duggal A","Mujanovic S","Scheraga RG","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Nonbronchoscopic Bronchoalveolar Lavage Improves Respiratory Culture Accuracy in Critically Ill Patients.","description":"<h4>Objectives</h4>Diagnosis of pneumonia is challenging in critically ill, intubated patients due to limited diagnostic modalities. Endotracheal aspirate (EA) cultures are standard of care in many ICUs; however, frequent EA contamination leads to unnecessary antibiotic use. Nonbronchoscopic bronchoalveolar lavage (NBBL) obtains sterile, alveolar cultures, avoiding contamination. However, paired NBBL and EA sampling in the setting of a lack of gold standard for airway culture is a novel approach to improve culture accuracy and limit antibiotic use in the critically ill patients.<h4>Design</h4>We designed a pilot study to test respiratory culture accuracy between EA and NBBL. Adult, intubated patients with suspected pneumonia received concurrent EA and NBBL cultures by registered respirator","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-22T18:02:44.319Z","creation":"2025-04-06T02:22:11.419Z"},"accession":"S-EPMC10656098","cross_references":{"pubmed":["38020848"],"doi":["10.1097/CCE.0000000000001008"]}}