{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(12)"],"submitter":["Nahshon C"],"pubmed_abstract":["<h4>Purpose</h4>To study the attitude of BRCA1/2 mutation carriers regarding family planning, fertility preservation, and preimplantation genetic testing (PGT).<h4>Methods</h4>A national cross-sectional study was conducted by the distribution of an anonymous questionnaire, from August 2022 to January 2023. The main outcomes measures were discussion, acceptance, and performance rates of fertility preservation and PGT.<h4>Results</h4>The questionnaire was completed by 530 BRCA1/2 mutation carriers. The mean (SD) age at mutation detection was 36.4 (9.6) years. At the time of mutation detection, 40% did not have children. Following mutation detection, 37% of responders changed their family planning, mostly choosing to have children earlier or to have less children than planned. Twenty-eight pe"],"journal":["Journal of assisted reproduction and genetics"],"pagination":["2835-2842"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10656383"],"repository":["biostudies-literature"],"pubmed_title":["Attitude of BRCA1/2 mutation carriers towards fertility preservation, family planning and preimplantation genetic testing for primary prevention of breast and ovarian cancer in the next generation."],"pmcid":["PMC10656383"],"pubmed_authors":["Oron G","Nahshon C","Lavie O"],"additional_accession":[]},"is_claimable":false,"name":"Attitude of BRCA1/2 mutation carriers towards fertility preservation, family planning and preimplantation genetic testing for primary prevention of breast and ovarian cancer in the next generation.","description":"<h4>Purpose</h4>To study the attitude of BRCA1/2 mutation carriers regarding family planning, fertility preservation, and preimplantation genetic testing (PGT).<h4>Methods</h4>A national cross-sectional study was conducted by the distribution of an anonymous questionnaire, from August 2022 to January 2023. The main outcomes measures were discussion, acceptance, and performance rates of fertility preservation and PGT.<h4>Results</h4>The questionnaire was completed by 530 BRCA1/2 mutation carriers. The mean (SD) age at mutation detection was 36.4 (9.6) years. At the time of mutation detection, 40% did not have children. Following mutation detection, 37% of responders changed their family planning, mostly choosing to have children earlier or to have less children than planned. Twenty-eight pe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-19T16:10:53.392Z","creation":"2025-04-19T16:10:53.392Z"},"accession":"S-EPMC10656383","cross_references":{"pubmed":["37751121"],"doi":["10.1007/s10815-023-02954-1"]}}