{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Lopes-Ribeiro A"],"pubmed_abstract":["<h4>Introduction and methods</h4>In this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral peptides using in silico and <i>in vitro</i> tools.<h4>Results</h4>In our results, HLA-A*02 haplotype showed the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, a decrease in combined prediction score was observed for HLA-A*02-restricted epitopes when the original strain was compared to the VOCs, indicating that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, which characterizes a immune evasion process. Additionally, epitope signature analysis revealed major immunogenic peptide loss for structural (S) and non-st"],"journal":["Frontiers in immunology"],"pagination":["1229712"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10656734"],"repository":["biostudies-literature"],"pubmed_title":["Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8<sup>+</sup> T cells."],"pmcid":["PMC10656734"],"pubmed_authors":["Oliveira PM","Barbosa-Stancioli EF","da Fonseca FG","Lopes-Ribeiro A","Tsuji M","Coelho-Dos-Reis JGA","Retes HM"],"additional_accession":[]},"is_claimable":false,"name":"Surveillance of SARS-CoV-2 immunogenicity: loss of immunodominant HLA-A*02-restricted epitopes that activate CD8<sup>+</sup> T cells.","description":"<h4>Introduction and methods</h4>In this present work, coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) were investigated for the presence of MHC-I immunodominant viral peptides using in silico and <i>in vitro</i> tools.<h4>Results</h4>In our results, HLA-A*02 haplotype showed the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, a decrease in combined prediction score was observed for HLA-A*02-restricted epitopes when the original strain was compared to the VOCs, indicating that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, which characterizes a immune evasion process. Additionally, epitope signature analysis revealed major immunogenic peptide loss for structural (S) and non-st","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-04-27T03:17:30.269Z","creation":"2025-04-05T19:22:55.442Z"},"accession":"S-EPMC10656734","cross_references":{"pubmed":["38022506"],"doi":["10.3389/fimmu.2023.1229712"]}}