biostudies-literatureUnknown10Rahim Khorasani M<h4>Background</h4>Ceftolozane/Tazobactam is a β-lactam/β-lactamase inhibitor combination with a high range of efficacy and broad-spectrum action against multidrug-resistant bacterial strains.<h4>Objectives</h4>The present study aimed to analyze the <i>in vitro</i> activity of Ceftolozane/Tazobactam against extended-spectrum β-lactamases (ESBLs)-producing <i>Escherichia coli</i> (ESBLs-EC) and <i>Klebsiella pneumonia</i> (ESBLs-KP) in the published literature to provide international data on the antimicrobial stewardship programs.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>A systematic literature search was conducted on the Web of Science, Embase, PubMed, Scopus, and Google Scholar electronic databases from the beginning of databases to December 2022 to cover all pubTherapeutic advances in infectious disease20499361231212074https://www.ebi.ac.uk/biostudies/studies/S-EPMC10656798biostudies-literatureGlobal evaluation of the antibacterial activity of Ceftolozane/Tazobactam against ESBLs-producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>: a systematic review and meta-analysis.PMC10656798Rahim Khorasani MRostami SSheikhi RBakhshi AfalseGlobal evaluation of the antibacterial activity of Ceftolozane/Tazobactam against ESBLs-producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>: a systematic review and meta-analysis.<h4>Background</h4>Ceftolozane/Tazobactam is a β-lactam/β-lactamase inhibitor combination with a high range of efficacy and broad-spectrum action against multidrug-resistant bacterial strains.<h4>Objectives</h4>The present study aimed to analyze the <i>in vitro</i> activity of Ceftolozane/Tazobactam against extended-spectrum β-lactamases (ESBLs)-producing <i>Escherichia coli</i> (ESBLs-EC) and <i>Klebsiella pneumonia</i> (ESBLs-KP) in the published literature to provide international data on the antimicrobial stewardship programs.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>A systematic literature search was conducted on the Web of Science, Embase, PubMed, Scopus, and Google Scholar electronic databases from the beginning of databases to December 2022 to cover all pub2023-01-01T00:00:00Z2023 Jan-Dec2025-04-21T18:22:14.205Z2025-04-05T17:12:08.671ZS-EPMC106567983802906810.1177/20499361231212074