biostudies-literatureJuckett LANIA NIH HHSPatient-Centered Outcomes Research Institute739https://www.ebi.ac.uk/biostudies/studies/S-EPMC10656935biostudies-literatureUnknown24(1)<h4>Background</h4>With recent growth in the conduct of pragmatic clinical trials, the reliance on frontline staff to contribute to trial-related activities has grown as well. Active partnerships with staff members are often critical to pragmatic trial implementation, but rarely do research teams track and evaluate the specific "implementation strategies" used to support staff's involvement in trial procedures (e.g., participant recruitment). Accordingly, we adapted implementation science methodologies and conducted an interim analysis of the strategies deployed with social service staff involved in one multi-site pragmatic clinical trial.<h4>Methods</h4>We used a naturalistic, observational study design to characterize strategies our research team deployed with staff during monthly, virtuTrialsPartnering with social service staff to implement pragmatic clinical trials: an interim analysis of implementation strategies.PMC10656935IHS-2020C3-21201U54 AG063546Juckett LAThomas KSBernard KPfalsePartnering with social service staff to implement pragmatic clinical trials: an interim analysis of implementation strategies.<h4>Background</h4>With recent growth in the conduct of pragmatic clinical trials, the reliance on frontline staff to contribute to trial-related activities has grown as well. Active partnerships with staff members are often critical to pragmatic trial implementation, but rarely do research teams track and evaluate the specific "implementation strategies" used to support staff's involvement in trial procedures (e.g., participant recruitment). Accordingly, we adapted implementation science methodologies and conducted an interim analysis of the strategies deployed with social service staff involved in one multi-site pragmatic clinical trial.<h4>Methods</h4>We used a naturalistic, observational study design to characterize strategies our research team deployed with staff during monthly, virtu2023-01-01T00:00:00Z2023 Nov2026-07-14T23:39:52.907Z2025-02-18T23:29:56.701ZS-EPMC106569353797852810.1186/s13063-023-07757-4