{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Zhou Z"],"pubmed_abstract":["<b>Background:</b> Currently, the mechanism(s) underlying corticogenesis is still under characterization. <b>Methods:</b> We curated the most comprehensive single-cell RNA-seq (scRNA-seq) datasets from mouse and human fetal cortexes for data analysis and confirmed the findings with co-immunostaining experiments. <b>Results:</b> By analyzing the developmental trajectories with scRNA-seq datasets in mice, we identified a specific developmental sub-path contributed by a cell-population expressing both deep- and upper-layer neurons (DLNs and ULNs) specific markers, which occurred on E13.5 but was absent in adults. In this cell-population, the percentages of cells expressing DLN and ULN markers decreased and increased, respectively, during the development suggesting direct neuronal transition ("],"journal":["Frontiers in cell and developmental biology"],"pagination":["1209320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10657809"],"repository":["biostudies-literature"],"pubmed_title":["Single-cell analysis reveals specific neuronal transition during mouse corticogenesis."],"pmcid":["PMC10657809"],"pubmed_authors":["Sun HX","Pan Y","Zhang D","Li J","Gu S","Zhou S","Dong Z","Zhou Z","Zhao L","Wang S","Zhu L","Cao Y","Jiang X","Lin G"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell analysis reveals specific neuronal transition during mouse corticogenesis.","description":"<b>Background:</b> Currently, the mechanism(s) underlying corticogenesis is still under characterization. <b>Methods:</b> We curated the most comprehensive single-cell RNA-seq (scRNA-seq) datasets from mouse and human fetal cortexes for data analysis and confirmed the findings with co-immunostaining experiments. <b>Results:</b> By analyzing the developmental trajectories with scRNA-seq datasets in mice, we identified a specific developmental sub-path contributed by a cell-population expressing both deep- and upper-layer neurons (DLNs and ULNs) specific markers, which occurred on E13.5 but was absent in adults. In this cell-population, the percentages of cells expressing DLN and ULN markers decreased and increased, respectively, during the development suggesting direct neuronal transition (","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-29T03:11:22.237Z","creation":"2025-04-20T01:04:21.142Z"},"accession":"S-EPMC10657809","cross_references":{"pubmed":["38020907"],"doi":["10.3389/fcell.2023.1209320"]}}