{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fang XZ"],"funding":["National Natural Science Foundation of China"],"pagination":["175-186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10658225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53"],"pubmed_abstract":["<h4>Introduction</h4>Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life-saving intervention for ARDS, it may cause the remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 is a mechanosensitive ion channel that is known to play a role in regulating diverse physiological processes, but whether Piezo1 is necessary for MV-exacerbated ARDS-associated pulmonary fibrosis remains unknown.<h4>Objectives</h4>This study aimed to explore the role of Piezo1 in MV-exacerbated ARDS-associated pulmonary fibrosis.<h4>Methods</h4>Human lung epithelial cells were stimulated with hydrochloric acid (HCl) followed by mechanical "],"journal":["Journal of advanced research"],"pubmed_title":["Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis."],"pmcid":["PMC10658225"],"funding_grant_id":["81971818","82002026","81772047","82172171","82272217"],"pubmed_authors":["Reng LH","Yuan SY","Xu JQ","Zhou T","Sun DY","Li M","Zhang P","Sun MM","Yang YY","He YJ","Shu HQ","Fang XZ","Shang Y","Li RT","Xu JX","Wang YX","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis.","description":"<h4>Introduction</h4>Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life-saving intervention for ARDS, it may cause the remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 is a mechanosensitive ion channel that is known to play a role in regulating diverse physiological processes, but whether Piezo1 is necessary for MV-exacerbated ARDS-associated pulmonary fibrosis remains unknown.<h4>Objectives</h4>This study aimed to explore the role of Piezo1 in MV-exacerbated ARDS-associated pulmonary fibrosis.<h4>Methods</h4>Human lung epithelial cells were stimulated with hydrochloric acid (HCl) followed by mechanical ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T11:35:48.804Z","creation":"2025-04-04T11:35:48.804Z"},"accession":"S-EPMC10658225","cross_references":{"pubmed":["36526145"],"doi":["10.1016/j.jare.2022.12.006"]}}