biostudies-literatureFang XZNational Natural Science Foundation of China175-186https://www.ebi.ac.uk/biostudies/studies/S-EPMC10658225biostudies-literatureUnknown53<h4>Introduction</h4>Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life-saving intervention for ARDS, it may cause the remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 is a mechanosensitive ion channel that is known to play a role in regulating diverse physiological processes, but whether Piezo1 is necessary for MV-exacerbated ARDS-associated pulmonary fibrosis remains unknown.<h4>Objectives</h4>This study aimed to explore the role of Piezo1 in MV-exacerbated ARDS-associated pulmonary fibrosis.<h4>Methods</h4>Human lung epithelial cells were stimulated with hydrochloric acid (HCl) followed by mechanical Journal of advanced researchMechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis.PMC106582258197181882002026817720478217217182272217Reng LHYuan SYXu JQZhou TSun DYLi MZhang PSun MMYang YYHe YJShu HQFang XZShang YLi RTXu JXWang YXYu YfalseMechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated ARDS-associated pulmonary fibrosis.<h4>Introduction</h4>Pulmonary fibrosis is a major cause of the poor prognosis of acute respiratory distress syndrome (ARDS). While mechanical ventilation (MV) is an indispensable life-saving intervention for ARDS, it may cause the remodeling process in lung epithelial cells to become disorganized and exacerbate ARDS-associated pulmonary fibrosis. Piezo1 is a mechanosensitive ion channel that is known to play a role in regulating diverse physiological processes, but whether Piezo1 is necessary for MV-exacerbated ARDS-associated pulmonary fibrosis remains unknown.<h4>Objectives</h4>This study aimed to explore the role of Piezo1 in MV-exacerbated ARDS-associated pulmonary fibrosis.<h4>Methods</h4>Human lung epithelial cells were stimulated with hydrochloric acid (HCl) followed by mechanical 2023-01-01T00:00:00Z2023 Nov2025-04-04T11:35:48.804Z2025-04-04T11:35:48.804ZS-EPMC106582253652614510.1016/j.jare.2022.12.006