{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen TS"],"funding":["Eun-Taek Han"],"pagination":["426"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10658926"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>The Plasmodium vivax merozoite restrictively invades immature erythrocytes, suggesting that its ligand(s) might interact with corresponding receptor(s) that are selectively abundant on reticulocytes to complete the invasion. Finding the ligand‒receptor interaction involved in P. vivax invasion is critical to vivax malaria management; nevertheless, it remains to be unraveled.<h4>Methods</h4>A library of reticulocyte receptors and P. vivax ligands were expressed by a HEK293E mammalian cell expression system and were then used to screen the interaction using enzyme-linked immunosorbent assay (ELISA). A flow cytometry-based erythrocyte binding assay and bio-layer interferometry experiment were further utilized to cellularly and quantitatively identify the ligand‒receptor int"],"journal":["Parasites & vectors"],"pubmed_title":["Plasmodium vivax merozoite-specific thrombospondin-related anonymous protein (PvMTRAP) interacts with human CD36, suggesting a novel ligand-receptor interaction for reticulocyte invasion."],"pmcid":["PMC10658926"],"funding_grant_id":["NRF-2021R1A2C2008235"],"pubmed_authors":["Chun W","Nguyen TS","Lee SK","Park WS","Park JH","Nguyen TV","Na SH","Nguyen TK","Lu F","Han ET","Han JH"],"additional_accession":[]},"is_claimable":false,"name":"Plasmodium vivax merozoite-specific thrombospondin-related anonymous protein (PvMTRAP) interacts with human CD36, suggesting a novel ligand-receptor interaction for reticulocyte invasion.","description":"<h4>Background</h4>The Plasmodium vivax merozoite restrictively invades immature erythrocytes, suggesting that its ligand(s) might interact with corresponding receptor(s) that are selectively abundant on reticulocytes to complete the invasion. Finding the ligand‒receptor interaction involved in P. vivax invasion is critical to vivax malaria management; nevertheless, it remains to be unraveled.<h4>Methods</h4>A library of reticulocyte receptors and P. vivax ligands were expressed by a HEK293E mammalian cell expression system and were then used to screen the interaction using enzyme-linked immunosorbent assay (ELISA). A flow cytometry-based erythrocyte binding assay and bio-layer interferometry experiment were further utilized to cellularly and quantitatively identify the ligand‒receptor int","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-20T01:02:59.092Z","creation":"2025-04-20T01:02:59.092Z"},"accession":"S-EPMC10658926","cross_references":{"pubmed":["37981686"],"doi":["10.1186/s13071-023-06031-5"]}}