biostudies-literatureUnknownArvidsson INIA NIH HHS<h4>Background</h4>Predicting future Alzheimer's disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be improved using entire brain images in deep learning (DL) models compared to using pre-defined brain regions.<h4>Methods</h4>A cohort of 332 individuals with SCD/MCI were included from the Swedish BioFINDER-1 study. The goal was to predict longitudinal SCD/MCI-to-AD dementia progression and change in Mini-Mental State Examination (MMSE) over four years. Four models were evaluated using diffResearch squarers.3.rs-3569391https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659533biostudies-literatureComparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer's disease in patients with mild cognitive symptoms.PMC10659533R01 AG083740Strandberg OPalmqvist SJanelidze STideman PHeyden AHansson OArvidsson IAstrom KMattsson-Carlgren NCullen NStomrud EfalseComparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer's disease in patients with mild cognitive symptoms.<h4>Background</h4>Predicting future Alzheimer's disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be improved using entire brain images in deep learning (DL) models compared to using pre-defined brain regions.<h4>Methods</h4>A cohort of 332 individuals with SCD/MCI were included from the Swedish BioFINDER-1 study. The goal was to predict longitudinal SCD/MCI-to-AD dementia progression and change in Mini-Mental State Examination (MMSE) over four years. Four models were evaluated using diff2023-01-01T00:00:00Z2023 Nov2025-05-29T21:47:04.371Z2025-02-19T01:16:35.129ZS-EPMC106595333798684110.21203/rs.3.rs-3569391/v1