biostudies-literatureUnknownCampbell TMNCI NIH HHS<h4>Purpose</h4>Breast cancer treatment is associated with weight gain, and obesity and its related cardiometabolic and hormonal risk factors have been associated with poorer outcomes. Dietary intervention may address these risk factors, but limited research has been done in the setting of metastatic breast cancer requiring systemic therapy.<h4>Methods</h4>Women with metastatic breast cancer on stable treatment were randomized 2:1 to an 8-week intervention (n = 21) or control (n = 11). The intervention included weekly assessment visits and an ad libitum whole food, plant-based (WFPB) diet with provided meals. Cardiometabolic, hormonal, and cancer markers were assessed at baseline, 4 weeks, and 8 weeks.<h4>Results</h4>Within the intervention group, mean weight decreased by 6.6% (p < 0.01) aResearch squarers.3.rs-3425125https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659540biostudies-literatureA Whole-Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Weight, Cardiometabolic, and Hormonal Outcome.PMC10659540UG1 CA189961Campbell TMWixom NGuido JBlanchard LHuston AJanelsins MCCampbell EKMoore RGFetten JPeppone LJMustian KMShayne MCulakova EfalseA Whole-Food, Plant-Based Randomized Controlled Trial in Metastatic Breast Cancer: Weight, Cardiometabolic, and Hormonal Outcome.<h4>Purpose</h4>Breast cancer treatment is associated with weight gain, and obesity and its related cardiometabolic and hormonal risk factors have been associated with poorer outcomes. Dietary intervention may address these risk factors, but limited research has been done in the setting of metastatic breast cancer requiring systemic therapy.<h4>Methods</h4>Women with metastatic breast cancer on stable treatment were randomized 2:1 to an 8-week intervention (n = 21) or control (n = 11). The intervention included weekly assessment visits and an ad libitum whole food, plant-based (WFPB) diet with provided meals. Cardiometabolic, hormonal, and cancer markers were assessed at baseline, 4 weeks, and 8 weeks.<h4>Results</h4>Within the intervention group, mean weight decreased by 6.6% (p < 0.01) a2023-01-01T00:00:00Z2023 Nov2025-04-04T19:27:55.706Z2024-11-20T03:01:28.947ZS-EPMC106595403798694010.21203/rs.3.rs-3425125/v1