biostudies-literatureAbdelmoaty MMMargaret R. Larson ProfessorshipNIA NIH HHSNIDA NIH HHSNIMH NIH HHSFogarty International CenterNINDS NIH HHSCarol Swarts, MD Emerging Neuroscience Research LaboratoryFrances and Louie Blumkin and Harriet Singer Research Foundations317-330https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659760biostudies-literatureUnknown2(3)<h4>Objectives</h4>To evaluate the linkage between age and deficits in innate and adaptive immunity which heralds both Alzheimer's disease (AD) onset and progression. The pathobiological events which underlie and tie these outcomes remain not fully understood.<h4>Methods</h4>To investigate age-dependent immunity in AD, we evaluated innate and adaptive immunity in coordinate studies of regulatory T cell (Treg) function, T cell frequencies, and microglial integrity. These were assessed in blood, peripheral lymphoid tissues, and the hippocampus of transgenic (Tg) amyloid precursor protein/presenilin 1 (APP/PS1) against non-Tg mice. Additionally, immune arrays of hippocampal tissue were performed at 4, 6, 12, and 20 months of age.<h4>Results</h4>APP/PS1 mice showed progressive impairment of TrNeuroImmune pharmacology and therapeuticsImmune senescence in aged APP/PS1 mice.PMC10659760P01 DA028555R01 NS036126P01 NS031492P30 MH062261P01 DA028555, R01 NS36126, P01 NS31492, P01 MH6457P01 NS043985R01 AG043540P01 MH064570R01 NS034239Yeapuri PGendelman HEMachhi JLu YKadry RBhattarai SLu EMosley RLAbdelmoaty MMNamminga KLfalseImmune senescence in aged APP/PS1 mice.<h4>Objectives</h4>To evaluate the linkage between age and deficits in innate and adaptive immunity which heralds both Alzheimer's disease (AD) onset and progression. The pathobiological events which underlie and tie these outcomes remain not fully understood.<h4>Methods</h4>To investigate age-dependent immunity in AD, we evaluated innate and adaptive immunity in coordinate studies of regulatory T cell (Treg) function, T cell frequencies, and microglial integrity. These were assessed in blood, peripheral lymphoid tissues, and the hippocampus of transgenic (Tg) amyloid precursor protein/presenilin 1 (APP/PS1) against non-Tg mice. Additionally, immune arrays of hippocampal tissue were performed at 4, 6, 12, and 20 months of age.<h4>Results</h4>APP/PS1 mice showed progressive impairment of Tr2023-01-01T00:00:00Z2023 Sep2025-04-20T01:04:17.692Z2025-04-20T01:04:17.692ZS-EPMC106597603802361410.1515/nipt-2023-0015