{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tyebally R"],"funding":["National Health and Medical Research Council (NHMRC)"],"pagination":["e1474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example."],"journal":["Clinical and translational medicine"],"pubmed_title":["The potential clinical impact of cell type-specific genetic regulation: Crohn's disease."],"pmcid":["PMC10659767"],"funding_grant_id":["1175781"],"pubmed_authors":["Xue A","Tyebally R","Powell JE"],"additional_accession":[]},"is_claimable":false,"name":"The potential clinical impact of cell type-specific genetic regulation: Crohn's disease.","description":"Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T20:37:22.009Z","creation":"2025-04-04T20:37:22.009Z"},"accession":"S-EPMC10659767","cross_references":{"pubmed":["37983917"],"doi":["10.1002/ctm2.1474"]}}