biostudies-literatureTyebally RNational Health and Medical Research Council (NHMRC)e1474https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659767biostudies-literatureUnknown13(11)Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example.Clinical and translational medicineThe potential clinical impact of cell type-specific genetic regulation: Crohn's disease.PMC106597671175781Xue ATyebally RPowell JEfalseThe potential clinical impact of cell type-specific genetic regulation: Crohn's disease.Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome-wide association studies (GWAS) integrated with single-cell expression quantitative trait loci analyses (eQTL) can pinpoint cell-type specific candidate disease-relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell-type specific genetic regulation, using Crohn's disease as an example.2023-01-01T00:00:00Z2023 Nov2025-04-04T20:37:22.009Z2025-04-04T20:37:22.009ZS-EPMC106597673798391710.1002/ctm2.1474