{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Perkins RK"],"funding":["NINR NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["e15859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659941"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(22)"],"pubmed_abstract":["BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m<sup>2</sup> ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m<sup>2</sup> ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO<sub>2</sub> max. Participants also completed a treadmill walking test at 65% VO<sub>2</sub> max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO<sub>2</sub> max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main "],"journal":["Physiological reports"],"pubmed_title":["Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals."],"pmcid":["PMC10659941"],"funding_grant_id":["DK109948","NR07760","R01 NR007760"],"pubmed_authors":["Miranda ER","Haus JM","Varshney P","Farabi SS","Quinn LT","Perkins RK"],"additional_accession":[]},"is_claimable":false,"name":"Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.","description":"BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m<sup>2</sup> ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m<sup>2</sup> ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO<sub>2</sub> max. Participants also completed a treadmill walking test at 65% VO<sub>2</sub> max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO<sub>2</sub> max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-18T19:44:08.821Z","creation":"2025-04-07T07:31:38.266Z"},"accession":"S-EPMC10659941","cross_references":{"pubmed":["37985201"],"doi":["10.14814/phy2.15859"]}}