biostudies-literaturePerkins RKNINR NIH HHSNational Institutes of HealthNIH HHSe15859https://www.ebi.ac.uk/biostudies/studies/S-EPMC10659941biostudies-literatureUnknown11(22)BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m² ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m² ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO₂ max. Participants also completed a treadmill walking test at 65% VO₂ max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO₂ max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main Physiological reportsEffects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.PMC10659941DK109948NR07760R01 NR007760Miranda ERHaus JMVarshney PFarabi SSQuinn LTPerkins RKfalseEffects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals.BMI-matched normal- (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m² ) and abnormal-glucose-tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m² ) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO₂ max. Participants also completed a treadmill walking test at 65% VO₂ max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p < 0.05) body fat % (+24%), fasting plasma glucose (+37%), OGTT AUC (+59%), and HOMA-IR (+55%) and lower (p < 0.05) VO₂ max (-24%). sTLR2 was 33% lower in AGT than NGT (main effect, p = 0.034). However, sTLR2 did not change (p > 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main 2023-01-01T00:00:00Z2023 Nov2025-04-18T19:44:08.821Z2025-04-07T07:31:38.266ZS-EPMC106599413798520110.14814/phy2.15859