biostudies-literatureUnknown4(4)Richardson PGDeeper responses are associated with longer survival in multiple myeloma (MM); however, limited data exist on the impact of response kinetics on outcomes. We investigated progression-free survival (PFS) and duration of response (DOR) by response depth and in early (best confirmed response 0-4 months; <i>n</i> = 424) versus late responders (best confirmed response >4 months; <i>n</i> = 281). Newly diagnosed patients enrolled in TOURMALINE-MM2 receiving ixazomib-lenalidomide-dexamethasone (IRd) (<i>n</i> = 351) or placebo-Rd (<i>n</i> = 354) were evaluated <i>post hoc</i>. Deeper responses were associated with longer PFS (complete response [CR] not reached [NR], very good partial response [VGPR] 37.2 months, partial response [PR] 16.4 months) and DOR (CR NR, VGPR 42.6 months, PR 15.4 months)EJHaem995-1005https://www.ebi.ac.uk/biostudies/studies/S-EPMC10660432biostudies-literatureLate versus early response and depth of response are associated with improved outcomes in patients with newly diagnosed multiple myeloma enrolled in the TOURMALINE-MM2 trial.PMC10660432Karlin LTwumasi-Ankrah PVoog ERajkumar SVYoon SSBahlis NJRifkin RMSuzuki KMoreau PVenner CPLonial SBenboubker LOffner FShibayama HRichardson PGZhang XKumar SKWhite DFacon TVillarreal MLabotka RfalseLate versus early response and depth of response are associated with improved outcomes in patients with newly diagnosed multiple myeloma enrolled in the TOURMALINE-MM2 trial.Deeper responses are associated with longer survival in multiple myeloma (MM); however, limited data exist on the impact of response kinetics on outcomes. We investigated progression-free survival (PFS) and duration of response (DOR) by response depth and in early (best confirmed response 0-4 months; <i>n</i> = 424) versus late responders (best confirmed response >4 months; <i>n</i> = 281). Newly diagnosed patients enrolled in TOURMALINE-MM2 receiving ixazomib-lenalidomide-dexamethasone (IRd) (<i>n</i> = 351) or placebo-Rd (<i>n</i> = 354) were evaluated <i>post hoc</i>. Deeper responses were associated with longer PFS (complete response [CR] not reached [NR], very good partial response [VGPR] 37.2 months, partial response [PR] 16.4 months) and DOR (CR NR, VGPR 42.6 months, PR 15.4 months)2023-01-01T00:00:00Z2023 Nov2026-07-14T20:01:42.462Z2025-02-19T04:25:55.365ZS-EPMC106604323802459310.1002/jha2.759