{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(4)"],"submitter":["Ruscitti P"],"pubmed_abstract":["<h4>Background</h4>Different patient clusters were preliminarily suggested to dissect the clinical heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters in a multicentre, observational, prospective study to stratify these patients.<h4>Methods</h4>Patients included in GIRRCS AOSD-study group and AIDA Network Still Disease Registry were assessed if variables for cluster analysis were available (age, systemic score, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and ferritin). K-means algorithm with Euclidean metric and Elbow plot were used to derive an adequate number of clusters.<h4>Results</h4>K-means clustering assessment provided four clusters based on means standardised according to z-scores on 349 patients. All clusters mainly pres"],"journal":["RMD open"],"pagination":["e003419"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10660445"],"repository":["biostudies-literature"],"pubmed_title":["Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry."],"pmcid":["PMC10660445"],"pubmed_authors":["Ruscitti P","Berardicurti O","Dagna L","Di Muzio C","Perosa F","Frediani B","Rossi S","Mauro D","Tufan A","Masedu F","Gidaro A","Asfina K","De Stefano L","Montecucco C","Carubbi F","Tharwat S","La Torre F","Govoni M","Giacomelli R","Ragab G","Bugatti S","Prete M","Sevik G","Guggino G","Ogunjimi B","Atzeni F","Sfikakis PP","Simonini G","Iagnocco A","Antonelli IPB","Caggiano V","Almaghlouth IA","Sfriso P","Di Cola I","Monti S","Del Giudice E","Fabiani C","Cipriani P","Lo Gullo A","Valenti M","Navarini L","Pantano I","Erten S","Hinojosa-Azaola A","Vitale A","Ciccia F","Caso F","Alibaz-Oner F","Cantarini L","Bartoloni E","Direskeneli H","Giardini H","Fotis L","Hernandez-Rodriguez J","Martin-Nares E","Costa L","Iacono D","Lopalco G","Makowska J","Maggio MC","Emmi G","Torres-Ruiz J","Maier A"],"additional_accession":[]},"is_claimable":false,"name":"Derivation and validation of four patient clusters in Still's disease, results from GIRRCS AOSD-study group and AIDA Network Still Disease Registry.","description":"<h4>Background</h4>Different patient clusters were preliminarily suggested to dissect the clinical heterogeneity in Still's disease. Thus, we aimed at deriving and validating disease clusters in a multicentre, observational, prospective study to stratify these patients.<h4>Methods</h4>Patients included in GIRRCS AOSD-study group and AIDA Network Still Disease Registry were assessed if variables for cluster analysis were available (age, systemic score, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and ferritin). K-means algorithm with Euclidean metric and Elbow plot were used to derive an adequate number of clusters.<h4>Results</h4>K-means clustering assessment provided four clusters based on means standardised according to z-scores on 349 patients. All clusters mainly pres","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-07-14T21:00:18.588Z","creation":"2026-06-24T03:06:56.259Z"},"accession":"S-EPMC10660445","cross_references":{"pubmed":["37989322"],"doi":["10.1136/rmdopen-2023-003419"]}}