biostudies-literatureLi Fthe Clinical Research Project of Shenzhen Dapeng New District Medicine and Health Groupthe Yu Miao Project of Shenzhen Dapeng New District Medicine and Health Group20361https://www.ebi.ac.uk/biostudies/studies/S-EPMC10663442biostudies-literatureUnknown13(1)Our study aimed to explore the association between serum C-reactive protein (CRP) and COVID-19 mortality. This is a retrospective cohort study of all patients admitted to 4 hospitals within the Montefiore Health System between March 1 and April 16, 2020, with SARS-CoV-2 infection. All-cause mortality were collected in 7 May 2020. The mortality risk was estimated using Cox proportional hazards models. Of the 3545 patients with a median age of 63.7 years, 918 (25.9%) died within the time of cohort data collection after admission. When the CRP was < 15.6 mg/L, the mortality rate increased with an adjusted HR of 1.57 (95% CI 1.30-1.91, P < 0.0001) for every 10 mg/L increment in the CRP. When the CRP was ≥ 15.6 mg/L, the mortality rate increased with an adjusted HR of 1.11 (95% CI 0.99-1.24, P Scientific reportsAssociation of C-reactive protein with mortality in Covid-19 patients: a secondary analysis of a cohort study.PMC10663442No.2022JTLCYJ06No.2021JTYM04Zhou MLai YLiu ZZhu YLi FHe MWang YfalseAssociation of C-reactive protein with mortality in Covid-19 patients: a secondary analysis of a cohort study.Our study aimed to explore the association between serum C-reactive protein (CRP) and COVID-19 mortality. This is a retrospective cohort study of all patients admitted to 4 hospitals within the Montefiore Health System between March 1 and April 16, 2020, with SARS-CoV-2 infection. All-cause mortality were collected in 7 May 2020. The mortality risk was estimated using Cox proportional hazards models. Of the 3545 patients with a median age of 63.7 years, 918 (25.9%) died within the time of cohort data collection after admission. When the CRP was < 15.6 mg/L, the mortality rate increased with an adjusted HR of 1.57 (95% CI 1.30-1.91, P < 0.0001) for every 10 mg/L increment in the CRP. When the CRP was ≥ 15.6 mg/L, the mortality rate increased with an adjusted HR of 1.11 (95% CI 0.99-1.24, P 2023-01-01T00:00:00Z2023 Nov2026-05-29T05:59:16.045Z2024-11-19T23:43:59.904ZS-EPMC106634423799006010.1038/s41598-023-47680-x