{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Valind K"],"funding":["Medicinska Fakulteten, Lunds Universitet","Region Skåne","Knut och Alice Wallenbergs Stiftelse","Lund University"],"pubmed_abstract":["<h4>Background</h4>Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([<sup>99m</sup>Tc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [<sup>99m</sup>Tc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [<sup>99m</sup>Tc]Tc-DMSA scintigraphy for renal cortical imaging. [<sup>18</sup>F]PSMA-1007 is a promising radiopharmaceutical for this purpose"],"journal":["European journal of hybrid imaging"],"pagination":["25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10667166"],"repository":["biostudies-literature"],"pubmed_title":["[<sup>18</sup>F]PSMA-1007 PET is comparable to [<sup>99m</sup>Tc]Tc-DMSA SPECT for renal cortical imaging."],"pmcid":["PMC10667166"],"pubmed_authors":["Valind K","Jogi J","Persson E","Minarik D","Garpered S","Tragardh E"],"additional_accession":[]},"is_claimable":false,"name":"[<sup>18</sup>F]PSMA-1007 PET is comparable to [<sup>99m</sup>Tc]Tc-DMSA SPECT for renal cortical imaging.","description":"<h4>Background</h4>Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([<sup>99m</sup>Tc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [<sup>99m</sup>Tc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [<sup>99m</sup>Tc]Tc-DMSA scintigraphy for renal cortical imaging. [<sup>18</sup>F]PSMA-1007 is a promising radiopharmaceutical for this purpose","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-21T21:06:01.345Z","creation":"2025-02-18T23:30:40.102Z"},"accession":"S-EPMC10667166","cross_references":{"pubmed":["37996712"],"doi":["10.1186/s41824-023-00185-2"]}}