biostudies-literatureUnknown7(1)Valind KMedicinska Fakulteten, Lunds UniversitetRegion SkåneKnut och Alice Wallenbergs StiftelseLund University<h4>Background</h4>Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([^99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [^99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [^99mTc]Tc-DMSA scintigraphy for renal cortical imaging. [¹⁸F]PSMA-1007 is a promising radiopharmaceutical for this purposeEuropean journal of hybrid imaging25https://www.ebi.ac.uk/biostudies/studies/S-EPMC10667166biostudies-literature[¹⁸F]PSMA-1007 PET is comparable to [^99mTc]Tc-DMSA SPECT for renal cortical imaging.PMC10667166Valind KJogi JPersson EMinarik DGarpered STragardh Efalse[¹⁸F]PSMA-1007 PET is comparable to [^99mTc]Tc-DMSA SPECT for renal cortical imaging.<h4>Background</h4>Scintigraphy using technetium-99m labelled dimercaptosuccinic acid ([^99mTc]Tc-DMSA), taken up in the proximal tubules, is the standard in functional imaging of the renal cortex. Recent guidelines recommend performing [^99mTc]Tc-DMSA scintigraphy with single photon emission computed tomography (SPECT). Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is used for staging and localization of recurrence in prostate cancer. A high renal uptake is often seen on PSMA PET, concordant with known PSMA expression in proximal tubules. This suggests PSMA PET could be used analogous to [^99mTc]Tc-DMSA scintigraphy for renal cortical imaging. [¹⁸F]PSMA-1007 is a promising radiopharmaceutical for this purpose2023-01-01T00:00:00Z2023 Nov2025-04-21T21:06:01.345Z2025-02-18T23:30:40.102ZS-EPMC106671663799671210.1186/s41824-023-00185-2