biostudies-literatureUnknown24(1)Gagnon PAQuebec Respiratory Health Research NetworkLouise Côté scholarship of Laval Universityle Fonds sur les maladies respiratoires J-D-Bégin P-H-Lavoie<h4>Rationale</h4>Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe asthma after considering biologics therapy. It was showed that BT long-lastingly improves asthma control. These improvements seem to be related to the ability of BT to reduce airway smooth muscle remodeling, reduce the number of nerve fibers and to modulate bronchial epithelium integrity and behavior. Current evidence suggest that BT downregulates epithelial mucins expression, cytokine production and metabolic profile. Despite these observations, biological mechanisms explaining asthma control improvement post-BT are still not well understood.<h4>Objectives</h4>To asRespiratory research294https://www.ebi.ac.uk/biostudies/studies/S-EPMC10668474biostudies-literatureS100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty.PMC10668474Chakir JAssou SGagnon PABiardel SLaviolette MDe Vos JLaprise CKlein MCote AGodbout KfalseS100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty.<h4>Rationale</h4>Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe asthma after considering biologics therapy. It was showed that BT long-lastingly improves asthma control. These improvements seem to be related to the ability of BT to reduce airway smooth muscle remodeling, reduce the number of nerve fibers and to modulate bronchial epithelium integrity and behavior. Current evidence suggest that BT downregulates epithelial mucins expression, cytokine production and metabolic profile. Despite these observations, biological mechanisms explaining asthma control improvement post-BT are still not well understood.<h4>Objectives</h4>To as2023-01-01T00:00:00Z2023 Nov2026-05-28T13:11:14.571Z2025-04-06T01:18:05.008ZS-EPMC106684743799695210.1186/s12931-023-02604-1