{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aravindraja C"],"funding":["NIDCR NIH HHS","National Institute of Dental and Craniofacial Research"],"pagination":["16393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10671577"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(22)"],"pubmed_abstract":["<i>T. forsythia</i> is a subgingival periodontal bacterium constituting the subgingival pathogenic polymicrobial milieu during periodontitis (PD). miRNAs play a pivotal role in maintaining periodontal tissue homeostasis at the transcriptional, post-transcriptional, and epigenetic levels. The aim of this study was to characterize the global microRNAs (miRNA, miR) expression kinetics in 8- and 16-week-old <i>T. forsythia</i>-infected C57BL/6J mouse mandibles and to identify the miRNA bacterial biomarkers of disease process at specific time points. We examined the differential expression (DE) of miRNAs in mouse mandibles (<i>n</i> = 10) using high-throughput NanoString nCounter<sup>®</sup> miRNA expression panels, which provided significant advantages over specific candidate miRNA or pathway "],"journal":["International journal of molecular sciences"],"pubmed_title":["Unique miRomics Expression Profiles in <i>Tannerella forsythia</i>-Infected Mandibles during Periodontitis Using Machine Learning."],"pmcid":["PMC10671577"],"funding_grant_id":["R01 DE028536"],"pubmed_authors":["Chan EKL","Duncan W","Bahadekar S","Kesavalu L","Jeepipalli S","Aravindraja C","Vekariya KM"],"additional_accession":[]},"is_claimable":false,"name":"Unique miRomics Expression Profiles in <i>Tannerella forsythia</i>-Infected Mandibles during Periodontitis Using Machine Learning.","description":"<i>T. forsythia</i> is a subgingival periodontal bacterium constituting the subgingival pathogenic polymicrobial milieu during periodontitis (PD). miRNAs play a pivotal role in maintaining periodontal tissue homeostasis at the transcriptional, post-transcriptional, and epigenetic levels. The aim of this study was to characterize the global microRNAs (miRNA, miR) expression kinetics in 8- and 16-week-old <i>T. forsythia</i>-infected C57BL/6J mouse mandibles and to identify the miRNA bacterial biomarkers of disease process at specific time points. We examined the differential expression (DE) of miRNAs in mouse mandibles (<i>n</i> = 10) using high-throughput NanoString nCounter<sup>®</sup> miRNA expression panels, which provided significant advantages over specific candidate miRNA or pathway ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-16T03:14:10.197Z","creation":"2026-06-16T03:07:04.644Z"},"accession":"S-EPMC10671577","cross_references":{"pubmed":["38003583"],"doi":["10.3390/ijms242216393"]}}