{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Serrath SN"],"funding":["PNPD/CAPES Pos-Doc (Programa Nacional de Pos Doutorado da CAPES)","Fundação de Amparo à Pesquisa do Estado de Rondônia (FAPERO)","National Council for Scientific and Technological Development","Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)","Network Technological Platforms","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)"],"pagination":["625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10674320"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(11)"],"pubmed_abstract":["L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of <i>Calloselasma rhodostoma</i> snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exos"],"journal":["Toxins"],"pubmed_title":["Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of <i>Calloselasma rhodostoma</i> Venom Action."],"pmcid":["PMC10674320"],"funding_grant_id":["001","311696/2021-0","306197/2017-0","405120/2018-4"],"pubmed_authors":["Cardozo DG","Zuliani JP","Boeno CN","Silva CP","Soares AM","Serrath SN","Ugarte AVE","Setubal SS","Santos LD","Silva MDS","Lopes JA","Cruz LF","Pontes AS","Paloschi MV","Santana HM","Magalhaes JGS","Cavecci-Mendonca B"],"additional_accession":[]},"is_claimable":false,"name":"Exosome Liberation by Human Neutrophils under L-Amino Acid Oxidase of <i>Calloselasma rhodostoma</i> Venom Action.","description":"L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of <i>Calloselasma rhodostoma</i> snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exos","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2026-06-11T03:16:09.324Z","creation":"2025-04-21T15:38:15.087Z"},"accession":"S-EPMC10674320","cross_references":{"pubmed":["37999488"],"doi":["10.3390/toxins15110625"]}}