{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van Sleen Y"],"funding":["Dutch Ministry of Health, Welfare and Sport","Innovative Medicines Initiative 2 Joint Undertaking"],"pagination":["68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10680197"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of"],"journal":["Immunity & ageing : I & A"],"pubmed_title":["Frailty is related to serum inflammageing markers: results from the VITAL study."],"pmcid":["PMC10680197"],"funding_grant_id":["806776"],"pubmed_authors":["Gutierrez-Melo N","van Baarle D","Toonen EJM","Sauce D","Buisman AM","van Sleen Y","Venema MCA","Shetty SA","van der Heiden M","van Beek J"],"additional_accession":[]},"is_claimable":false,"name":"Frailty is related to serum inflammageing markers: results from the VITAL study.","description":"Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-22T18:09:25.189Z","creation":"2025-04-06T02:22:03.319Z"},"accession":"S-EPMC10680197","cross_references":{"pubmed":["38012652"],"doi":["10.1186/s12979-023-00391-3"]}}