biostudies-literaturevan Sleen YDutch Ministry of Health, Welfare and SportInnovative Medicines Initiative 2 Joint Undertaking68https://www.ebi.ac.uk/biostudies/studies/S-EPMC10680197biostudies-literatureUnknown20(1)Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains ofImmunity & ageing : I & AFrailty is related to serum inflammageing markers: results from the VITAL study.PMC10680197806776Gutierrez-Melo Nvan Baarle DToonen EJMSauce DBuisman AMvan Sleen YVenema MCAShetty SAvan der Heiden Mvan Beek JfalseFrailty is related to serum inflammageing markers: results from the VITAL study.Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing.Frailty measures and inflammageing markers were assessed in 317 participants aged 25-90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of2023-01-01T00:00:00Z2023 Nov2025-04-22T18:09:25.189Z2025-04-06T02:22:03.319ZS-EPMC106801973801265210.1186/s12979-023-00391-3