{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Faleye OS"],"funding":["Ministry of Education","Ministry of Science, ICT and Future Planning","National Research Foundation of Korea"],"pagination":["100165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10681883"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["<i>Vibrio parahaemolyticus</i> is a high-risk foodborne pathogen associated with raw or undercooked seafoods and its biofilm forming potential has become a threat to food safety and economic values. Hence, this study aims to examine the antibacterial and antibiofilm activities as well as virulence inhibitory effects of selected flavonoids against <i>V. parahaemolyticus</i>. Out of the sixteen flavonoid derivatives, 6-aminoflavone (6-AF), 3,2-dihydroxyflavone (3,2-DHF) and 2,2-dihydroxy-4-methoxybenzophenone (DHMB) were found as active biofilm inhibitors. 3,2-DHF and DHMB had minimum inhibitory concentrations of 20 and 50 μg/mL respectively against <i>Vibrio</i> planktonic cells and displayed superior antibacterial activities to standard controls. Also, they disrupted preformed biofilms and"],"journal":["Biofilm"],"pubmed_title":["Selected flavonoids exhibit antibiofilm and antibacterial effects against <i>Vibrio</i> by disrupting membrane integrity, virulence and metabolic activities."],"pmcid":["PMC10681883"],"funding_grant_id":["2021R1A2C1008368","2021R1I1A3A04037486"],"pubmed_authors":["Lee J","Faleye OS","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Selected flavonoids exhibit antibiofilm and antibacterial effects against <i>Vibrio</i> by disrupting membrane integrity, virulence and metabolic activities.","description":"<i>Vibrio parahaemolyticus</i> is a high-risk foodborne pathogen associated with raw or undercooked seafoods and its biofilm forming potential has become a threat to food safety and economic values. Hence, this study aims to examine the antibacterial and antibiofilm activities as well as virulence inhibitory effects of selected flavonoids against <i>V. parahaemolyticus</i>. Out of the sixteen flavonoid derivatives, 6-aminoflavone (6-AF), 3,2-dihydroxyflavone (3,2-DHF) and 2,2-dihydroxy-4-methoxybenzophenone (DHMB) were found as active biofilm inhibitors. 3,2-DHF and DHMB had minimum inhibitory concentrations of 20 and 50 μg/mL respectively against <i>Vibrio</i> planktonic cells and displayed superior antibacterial activities to standard controls. Also, they disrupted preformed biofilms and","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2025-04-22T08:27:12.715Z","creation":"2025-02-19T04:44:18.142Z"},"accession":"S-EPMC10681883","cross_references":{"pubmed":["38034415"],"doi":["10.1016/j.bioflm.2023.100165"]}}