{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sykora M"],"funding":["VEGA","Agentúra na Podporu Výskumu a Vývoja","Ministry of Health of the Czech Republic","National Institute for Research of Metabolic and Cardiovascular Diseases (Program EXCELES","European Regional Development Fund"],"pagination":["20923"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10684879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Heart failure (HF) is life-threatening disease due to electro-mechanical dysfunction associated with hemodynamic overload, while alterations of extracellular matrix (ECM) along with perturbed connexin-43 (Cx43) might be key factors involved. We aimed to explore a dual impact of pressure, and volume overload due to aorto-caval fistula (ACF) on Cx43 and ECM as well as effect of renin-angiotensin blockade. Hypertensive Ren-2 transgenic rats (TGR) and normotensive Hannover Sprague-Dawley rats (HSD) that underwent ACF were treated for 15-weeks with trandolapril or losartan. Blood serum and heart tissue samples of the right (RV) and left ventricles (LV) were used for analyses. ACF-HF increased RV, LV and lung mass in HSD and to lesser extent in TGR, while treatment attenuated it and normalized s"],"journal":["Scientific reports"],"pubmed_title":["The treatment with trandolapril and losartan attenuates pressure and volume overload alternations of cardiac connexin-43 and extracellular matrix in Ren-2 transgenic rats."],"pmcid":["PMC10684879"],"funding_grant_id":["21-0410","00023001","ITMS2014+: 313011AVG3","LX22NPO5104","2/0002/20","2/0006/23"],"pubmed_authors":["Tribulova N","Kopkan L","Cervenka L","Kratky V","Szeiffova Bacova B","Sykora M"],"additional_accession":[]},"is_claimable":false,"name":"The treatment with trandolapril and losartan attenuates pressure and volume overload alternations of cardiac connexin-43 and extracellular matrix in Ren-2 transgenic rats.","description":"Heart failure (HF) is life-threatening disease due to electro-mechanical dysfunction associated with hemodynamic overload, while alterations of extracellular matrix (ECM) along with perturbed connexin-43 (Cx43) might be key factors involved. We aimed to explore a dual impact of pressure, and volume overload due to aorto-caval fistula (ACF) on Cx43 and ECM as well as effect of renin-angiotensin blockade. Hypertensive Ren-2 transgenic rats (TGR) and normotensive Hannover Sprague-Dawley rats (HSD) that underwent ACF were treated for 15-weeks with trandolapril or losartan. Blood serum and heart tissue samples of the right (RV) and left ventricles (LV) were used for analyses. ACF-HF increased RV, LV and lung mass in HSD and to lesser extent in TGR, while treatment attenuated it and normalized s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-22T08:11:09.011Z","creation":"2025-02-19T04:44:04Z"},"accession":"S-EPMC10684879","cross_references":{"pubmed":["38017033"],"doi":["10.1038/s41598-023-48259-2"]}}